|
KMID : 0356919960300020238
|
|
Korean Journal of Anesthesiology
1996 Volume.30 No. 2 p.238 ~ p.239
|
|
|
Letters to Editor
|
|
|
|
|
Abstract
|
|
|
Background:
@EN We have previously demonstrated the isoflurane and halothane may be detrimental to in vitro fertilization of mouse oocytes in high concentration. The aim of this study is to compare the toxic effects of volatile anesthetics on mouse embryos
using in
vitro growth model of two cell mouse embryos.
Methods: Mouse two-cell embryos exposed to three volatile anesthetics, enflurane(0.5 mM; 1.5mM), isoflurane(0.26mM; 0.78mM) and halothane(0.24mM; 0.72mM). Mouse two-cell embryos unexposed to any drugs were included as controls.
@ES Results: The percentages of two-cell mouse embryos developed over morula stages on the third day after exposure of high concentrations of isoflurane and halothane decreased significantly compared with controls. The rates of embryos arrested
at
2~8
cell stage in these groups were significantly higher than that of controls. There were no significant differences in these rates between enflurane group, isoflurane and halothane group of lower concentration and controls. The hatching and/or
hatched
blastocysts development were significantly lower in isoflurane and halothane group than in controls. No significant differences in the hatching rate of blastocyst developed were observed among groups.
@ES Conclusions:
@EN Our data show that isoflurane and halothane in high concentrations have harm effects of the in vitro growth of two cell mouse embryos. (Korean J Anesthesiol 1996; 30: 245~251).
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
   
|